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Neurology. 2004 Jun 8;62(11):2110-2.

The effect of combined thrombolysis with rtPA and tirofiban on ischemic brain lesions.

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  • 1Department of Neurology, Heinrich-Heine University of Düsseldorf, Germany.


To determine the effect of systemic thrombolysis with low-dose recombinant tissue plasminogen activator (rtPA) and the body-weight adjusted platelet GPIIb/IIIa receptor antagonist tirofiban, the authors performed lesion volumetry on magnetic resonance perfusion and diffusion images recorded before thrombolysis and on T2-weighted magnetic resonance images on day 8. Treatment with rtPA and tirofiban (n = 13) resulted in a 50% lesion reduction (p < 0.03), while lesion reduction was less in rtPA treatment (n = 16) and absent in nontreated patients (n = 18).

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