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Neurology. 2004 Jun 8;62(11):2005-9.

Apolipoprotein E controls the risk and age at onset of Parkinson disease.

Author information

1
Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA. yiju.li@duke.edu

Abstract

BACKGROUND:

Similarities between Alzheimer disease (AD) and Parkinson disease (PD) suggest a possible role for apolipoprotein E (APOE) in PD. Most previous studies seeking to establish such a link used case-control datasets and results have been inconsistent.

OBJECTIVE:

To investigate APOE's role in PD using family-based association analyses.

METHODS:

APOE functional polymorphisms were genotyped for 658 PD affected families, including 282 multiplex and 376 singleton families. The pedigree disequilibrium test (PDT) and the genotype-PDT were used to test the risk effect of APOE. The Monks-Kaplan test was used to evaluate the effect of APOE on age at onset of PD.

RESULTS:

APOE was significantly associated with risk of developing PD. Stratified analysis revealed that APOE was most strongly associated with families with a positive PD family history (global p = 0.003). Like AD, the APOE-4 allele increases disease risk while the APOE-3 allele decreases risk. We detected a positive association of APOE-3 (p = 0.019) and a negative association of APOE-4 (p = 0.015) with age at onset in PD.

CONCLUSIONS:

The APOE-4 allele increases risk and decreases age at onset of PD, an association that may not be dependent upon cognitive impairment.

[Indexed for MEDLINE]

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