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Am J Ophthalmol. 2004 Jun;137(6):1142-3.

Serum levels of triamcinolone acetonide after intravitreal injection.

Author information

1
Department of Ophthalmology, Faculty for Clinical Medicine Mannheim, Ruprecht-Karls-University, Heidelberg, Mannheim, Germany. robert.degenring@augen.ma.uni-heidelberg.de

Abstract

PURPOSE:

To evaluate serum levels of triamcinolone acetonide after intravitreal high-dose injection.

DESIGN:

Prospective, interventional case series study.

METHODS:

For 20 consecutive patients, venous blood samples were taken before and 13 +/- 19 days (range 4 to 92) after an intravitreal injection of 20 to 25 mg triamcinolone acetonide as treatment of edematous macular diseases.

RESULTS:

Serum levels of triamcinolone acetonide did not differ significantly (P =.174; t test for paired matches) preoperatively (0 microg/l) and postoperatively (0.065 microg/l +/- 0.21 microg/l). In 18 eyes (90%), triamcinolone acetonide could not be detected in serum samples. For two patients (10%), serum samples taken 5 days and 7 days after the injection, respectively, contained 0.5 microg/l triamcinolone acetonide and 0.8 microg/l triamcinolone acetonide, respectively.

CONCLUSION:

After an intravitreal high-dose injection of 20 to 25 mg triamcinolone acetonide, triamcinolone acetonide is not, or only marginally, detectable in serum samples obtained within 4 to 92 days after the injection.

PMID:
15183810
DOI:
10.1016/j.ajo.2004.01.008
[Indexed for MEDLINE]

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