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Int J Oral Maxillofac Surg. 2004 Jul;33(5):512-4.

Clear cell odontogenic carcinoma-a case report and review of literature.

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Department of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka.


The clear cell odontogenic carcinoma (CCOC) is a rare, locally infiltrative neoplasm with a marked tendency for local recurrence and regional lymph node metastasis. The first description in 1985 included three cases of destructive jaw lesions. The entity was described as a clear cell odontogenic tumour in the previous WHO classification due to the fact that rarity of the lesion restricting pathologists to understand the spectrum of the degree of malignancy. These tumours have a peak incidence in the 5th-7th decades. CCOC tends to occur more frequently in the mandible, with a female predilection. The most striking histological feature is of large islands and strands of uniform cells with round or ovoid nuclei and clear cytoplasm. Presently we describe a case of clear cell odontogenic carcinoma in a 52-year-old female who presented with a bony-hard lump in the left body of the mandible. The patient is free of any recurrence after 2 years of follow-up.

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