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Drug Discov Today. 2004 Jun 15;9(12):517-24.

Evaluating the validity of animal models for research into therapies for immune-based disorders.

Author information

1
Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, The Netherlands. hart@bprc.nl

Abstract

The last few decades of the 20th century have shown an intensified search for safer and more effective medications against chronic diseases that burden ageing societies of the western world. The impressive development of biotechnological production techniques has greatly facilitated the pharmaceutical development of relatively non-toxic biological molecules. However, despite the huge investments, only a few effective therapies for immune-based diseases have reached the clinic. In this article we use examples from monoclonal antibody trials to discuss the validity and predictive strength of the animal models currently used for the development of effective therapies.

PMID:
15183159
DOI:
10.1016/S1359-6446(04)03112-5
[Indexed for MEDLINE]

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