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J Ethnopharmacol. 2004 Jul;93(1):89-92.

In vitro antibradykinin activity of Aloe barbadensis gel.

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Laboratorio de Farmacología, División de Investigación y Postgrado, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Av., De los Barrios 1, Los Reyes Iztacala, Tlalnepantla, Mexico, CP 54090, Mexico.


When bradykinin-induced contraction of the isolated rat ileum was tested in the presence of Aloe barbadensis Mill. (Liliaceae) gel (fraction F-1) and with the fraction obtained by precipitation of the F-1 with 55% ammonium sulfate (F-55), the maximal responses to bradykinin were reduced by 10 and 22%, respectively. Furthermore, purification of the F-55 by filtration through a column of Sephacryl (S-500-HR) yielded the F-SH fraction, which inhibited the bradykinin effect by 60%. Purification of the F-SH fraction, by filtration through a column of Sephadex G-100, brought about four new fractions: F-GA, F-GB, F-GC, and F-GD. F-GB was the only one that showed the bradykinin inhibition effect (67%). Clearly, Aloe barbadensis gel contains a material that inhibits the bradykinin effect, which might explain the anti-inflammatory properties of Aloe barbadensis.

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