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Curr Biol. 2004 Jun 8;14(11):R436-7.

Wnt signaling: Ig-norrin the dogma.

Author information

1
Hubrecht Laboratory, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands. clevers@niob.knaw.nl

Abstract

Secreted Wnt proteins trigger the intracellular Wnt signaling cascade upon engagement of dedicated Frizzled-Lrp receptor complexes. Unexpectedly, a non-Wnt ligand for this receptor complex has now been discovered. This novel ligand, Norrin, is mutated in the hereditary ocular Norrie syndrome.

PMID:
15182694
DOI:
10.1016/j.cub.2004.05.039
[Indexed for MEDLINE]
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