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Biochem J. 2004 Aug 1;381(Pt 3):587-92.

PKA-phosphorylation of PDE4D3 facilitates recruitment of the mAKAP signalling complex.

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1
Howard Hughes Medical Institute and Vollum Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239-3098, USA.

Abstract

mAKAP (muscle-selective A-kinase-anchoring protein) co-ordinates a cAMP-sensitive negative-feedback loop comprising PKA (cAMP-dependent protein kinase) and the cAMP-selective PDE4D3 (phosphodiesterase 4D3). In vitro and cellular experiments demonstrate that PKA-phosphorylation of PDE4D3 on Ser-13 increases the affinity of PDE4D3 for mAKAP. Our data suggest that activation of mAKAP-anchored PKA enhances the recruitment of PDE4D3, allowing for quicker signal termination.

PMID:
15182229
PMCID:
PMC1133866
DOI:
10.1042/BJ20040846
[Indexed for MEDLINE]
Free PMC Article
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