Format

Send to

Choose Destination
See comment in PubMed Commons below
Adv Exp Med Biol. 2003;533:221-7.

Does constitutive phosphorylation protect against photoreceptor degeneration in Rpe65-/- mice?

Author information

1
Department of Ophthalmology, Medical University of South Carolina, Charleston, SC, USA. rohrer@musc.edu

Abstract

Despite the presence of this virgin opsin, Rpe65-/- rods are behaving like dark-adapted rods. These results argue that opsin which has not been exposed to 11-cis retinal and is constitutively phosphorylated, does not generate the activity generally associated with the bleached apoprotein. However, increased light-independent activation of transducin (due to bleached opsin) could be demonstrated after the addition of exogenous 11-cis retinal. We hypothesize that free opsin in the Rpe65-/- rods does not cause degeneration of rods by constitutive activation of the phototransduction cascade; but rather rods may die due to other causes such as the impairment of RPE function due to excess unprocessed retinyl-esters in the RPE.

PMID:
15180268
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center