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Psychoneuroendocrinology. 2004 Aug;29(7):825-9.

Pulsatile luteinizing hormone disruption in depression.

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Division of Biostatistics, School of Public Health MMC303, University of Minnesota, 412 Delaware Street SE, Mayo A-460, Minneapolis, MN 55455, USA.


Two independent groups recently published data comparing pulsatile luteinizing hormone (LH) release between depressed and control women. Despite similar populations and LH sampling frequency, they reached different conclusions: Meller et al. [Am. J. Psych. 154 (1997) 1454] found disruption of normal LH pulsatility in depressed women, whereas Young et al. [Arch. Gen. Psych. 57 (2000) 1157] did not. To resolve this discrepancy, the current study applies a single, well-established statistical method, spectral analysis, to the two data sets and concludes that both depressed populations display significantly altered LH pulsatile release.

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