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Bioorg Med Chem Lett. 2004 Jul 5;14(13):3481-6.

Synthesis and biological activity of some known and putative duloxetine metabolites.

Author information

1
Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285 USA. kuo_fengjiun@lilly.com

Erratum in

  • Bioorg Med Chem Lett. 2004 Oct 18;14(20):5233.

Abstract

Several putative phase I duloxetine metabolites, 4-hydroxy-, 5-hydroxy-, 6-hydroxy-, 5-hydroxy-6-methoxy-, 6-hydroxy-5-methoxy-, 5,6-dihydroxy-, and 4,6-dihydroxyduloxetine were synthesized, and their phase II metabolite as glucuronide or sulfate conjugates were also synthesized. Their in vitro binding activities were compared to that of parent compound duloxetine.

PMID:
15177457
DOI:
10.1016/j.bmcl.2004.04.066
[Indexed for MEDLINE]

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