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Bioorg Med Chem Lett. 2004 Jul 5;14(13):3441-4.

2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones: functionally selective benzodiazepine binding site ligands on the GABAA receptor.

Author information

1
Merck Sharp & Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow CM20 2QR, UK. andrew_mitchinson@merck.com

Abstract

2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones are GABAA receptor benzodiazepine binding site ligands with functional selectivity for the alpha3 subtype over the alpha1 subtype. SAR studies to optimise this functional selectivity are described.

PMID:
15177449
DOI:
10.1016/j.bmcl.2004.04.085
[Indexed for MEDLINE]

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