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Expert Rev Vaccines. 2004 Jun;3(3):249-67.

A review of the efficacy, immunogenicity and tolerability of a combined hepatitis A and B vaccine.

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Unit of Epidemiology and Social Medicine, Centre for the Evaluation of Vaccination, WHO Collaborating Centre for the Prevention and Control of Viral Hepatitis, University of Antwerp, Campus 3 Eiken, Wilrijk, Belgium.


Hepatitis A and B are two of the most common vaccine-preventable liver diseases and continue to be a significant cause of morbidity and mortality worldwide, with their severity related to the individual's age upon initial infection. Twinrix (GlaxoSmithKline), a combined vaccine providing protection against both hepatitis A and B, has been available in more than 72 countries worldwide since 1997. This paper provides a critical review of clinical data on the efficacy, immunogenicity and tolerability of the combined vaccine, with particular focus on the clinical benefits of dual vaccination.

[Indexed for MEDLINE]

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