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Mol Cell. 2004 Jun 4;14(5):667-73.

Removal of promoter nucleosomes by disassembly rather than sliding in vivo.

Author information

1
Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

Previous work demonstrated the removal of nucleosomes from the PHO5 promoter upon transcriptional activation in yeast. Removal could occur by nucleosome disassembly or by sliding of nucleosomes away from the promoter. We have now activated the PHO5 promoter on chromatin circles following excision from the chromosomal locus. Whereas sliding would conserve the number of nucleosomes on the circle, we found that the number was diminished, demonstrating chromatin remodeling by nucleosome disassembly.

PMID:
15175161
DOI:
10.1016/j.molcel.2004.05.013
[Indexed for MEDLINE]
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