Format

Send to

Choose Destination
Curr Opin Genet Dev. 2004 Jun;14(3):292-300.

Redundancy, insult-specific sensors and thresholds: unlocking the S-phase checkpoint response.

Author information

1
Department of Molecular Biology and the NCCR Frontiers in Genetics, University of Geneva, Quai Ernest-Ansermet 30, CH-1211 Geneva 4, Switzerland.

Abstract

DNA damage that is not properly repaired during genomic replication is a major source of gross chromosomal rearrangements and sequence loss during cell proliferation. In higher eukaryotes such mutations increase the risk of cancer. Eukaryotic cells have multiple checkpoint responses activated by DNA damage and stalled replication forks. We focus here on fork-associated events that activate and respond to S-phase checkpoint kinases.

PMID:
15172673
DOI:
10.1016/j.gde.2004.04.001
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center