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Am J Psychiatry. 2004 Jun;161(6):1023-9.

Cerebellar, prefrontal cortex, and thalamic volumes over two time points in adolescent-onset schizophrenia.

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1
Highfield Adolescent Unit, Warneford Hospital, Oxford, UK. anthony.james@psych.ox.ac.uk

Abstract

OBJECTIVE:

Structural and functional studies implicate multiple brain lesions as a basis for a functional dysconnectivity underlying the cognitive and symptom profiles in schizophrenia. The aim of this study was to examine the hypothesis that early-onset schizophrenia is associated with structural abnormalities in the prefrontal cortex, thalamus, and cerebellum, compatible with a dysconnectivity syndrome.

METHOD:

Two magnetic resonance imaging scans of 16 patients and 16 normal comparison subjects were undertaken on average 2 to 3 years apart. The participants were all from a defined geographic area in the United Kingdom with a population of 2.5 million.

RESULTS:

In comparison to the normal adolescents, the schizophrenic subjects demonstrated low prefrontal cortex and thalamic volumes. The relatively large difference in prefrontal and thalamic volumes in these adolescents with schizophrenia implies a more severe disease process than in adult subjects.

CONCLUSIONS:

The thalamic and frontal lobe findings provide preliminary, supportive structural evidence for a neurodevelopmental basis for a dysconnectivity syndrome, although the cerebellar findings were inconclusive.

PMID:
15169690
DOI:
10.1176/appi.ajp.161.6.1023
[Indexed for MEDLINE]
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