Aim of the study was the use of IC-View for monitoring the effect of V.A.C.(R)-therapy on perfusion in diabetic wounds and the surrounding skin. We present data of ten patients with diabetic foot syndrome. Seven men and three women with age from 56 to 86 (mean 68) years were treated with V.A.C.(R)-therapy for 7 to 24 (mean 12) days. The perfusion index was calculated for the wound itself and for the surrounding skin before and at the end of V.A.C.(R)-therapy. The perfusion of the wound showed an increase under V.A.C.(R)-therapy of 31 % (6-62.5 %). The perfusion index calculated for the skin around the defect achieved an increase of 14 % (1.5-38 %). All defects were covered with meshed skin graft.