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Am J Obstet Gynecol. 2004 May;190(5):1432-4.

Coenzyme Q10 and lipid-related gene induction in HeLa cells.

Author information

1
Albert Einstein College of Medicine, Albert Einstein Cancer Center and Montefiore Medical Center Bronx, NY 10467, USA.

Abstract

OBJECTIVE:

Coenzyme Q10 is an antioxidant that may have a therapeutic role in cervical cancer.

STUDY DESIGN:

We investigated the cellular and molecular effects of 30 micromol/L Coenzyme Q10 in HeLa cells. Cell growth assays, fluorescence-activated cell sorting analyses, and Oil Red O staining were performed. Microarray experiments were performed in duplicate and analyzed on the basis of 2-fold changes in levels of gene expression.

RESULTS:

Coenzyme Q10 inhibited cell growth and led to apoptosis. Microarray analysis showed that 264 sequences were altered over time, with enrichment in lipid-related genes. Enhanced lipid accumulation was confirmed with Oil Red O staining.

CONCLUSION:

A lipid response to Coenzyme Q10 may affect mechanisms of growth inhibition in HeLa cells.

PMID:
15167860
DOI:
10.1016/j.ajog.2004.01.076
[Indexed for MEDLINE]

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