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Neuroreport. 2004 Jun 7;15(8):1315-9.

Changes in functional connectivity of human MT/V5 with visual motion input.

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Department of Diagnostic Radiology, Yale School of Medicine, P.O. Box 208043, New Haven, CT 06510, USA.


The neural basis of human mental function is characterized by interactions between brain regions. Temporal correlations in MR signals between areas may provide one method for investigating these interactions. This approach was used to examine functional connectivity in the motion processing system of the human brain. Correlations between MT/V5 and other brain regions were examined in a resting state (without visual stimulation) and in an active state produced by viewing moving concentric circles. A network of regions consistent with the known functional anatomy of visual processing was correlated with MT/V5 during rest. When subjects were viewing motion, a more limited network was correlated with MT/V5, suggesting MT/V5 was acting in concert with a smaller network specific to the task.

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