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Biochim Biophys Acta. 2004 Mar 22;1636(2-3):219-31.

Functions and biosynthesis of plasmalogens in health and disease.

Author information

1
Department of Clinical Chemistry, Academic Medical Center, Lab Genetic Metabolic Diseases, F0-224, Meibergdreef 9, Amsterdam 1105 AZ, Netherlands.

Abstract

Plasmalogens (1-O-alk-1'-enyl-2-acyl glycerophospholipids) constitute a special class of phospholipids characterized by the presence of a vinyl-ether bond at the sn-1 position. Although long considered as biological peculiarities, interest in this group of phospholipids has grown in recent years, thanks to the realization that plasmalogens are involved in different human diseases. In this review, we summarize the current state of knowledge with respect to the enzymatic synthesis of plasmalogens, the characteristic topology of the enzymes involved and the biological roles that have been assigned to plasmalogens.

PMID:
15164770
DOI:
10.1016/j.bbalip.2003.12.010
[Indexed for MEDLINE]

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