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Chest. 1992 Sep;102(3):959-60.

Treatment of life-threatening primary pulmonary hemosiderosis with cyclophosphamide.

Author information

1
Department of Pediatrics, University of Nebraska Medical Center, Omaha 68198-5190.

Abstract

This report describes a five-year-old boy with severe pulmonary hemorrhage caused by primary pulmonary hemosiderosis with cow's milk sensitivity. After failing to respond to corticosteroids and azathioprine, he dramatically improved after being given cyclophosphamide. He worsened after discontinuation of cyclophosphamide on two occasions and improved significantly with its reinstitution. Cyclophosphamide was continued for 14 months without further bleeding or adverse effects. The patient has remained in remission for nearly five years. Cyclophosphamide may be a life-saving alternative therapy for refractory pulmonary hemorrhage with pulmonary hemosiderosis.

PMID:
1516434
DOI:
10.1378/chest.102.3.959
[Indexed for MEDLINE]

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