Format

Send to

Choose Destination
Nat Struct Mol Biol. 2004 Jun;11(6):503-11.

The mRNA cap-binding protein eIF4E in post-transcriptional gene expression.

Author information

1
Post-transcriptional Control Group, Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, PO Box 88, Manchester M60 1QD, UK. Tobias.von-der-Haar@umist.ac.uk

Abstract

Eukaryotic initiation factor 4E (eIF4E) has central roles in the control of several aspects of post-transcriptional gene expression and thereby affects developmental processes. It is also implicated in human diseases. This review explores the relationship between structural, biochemical and biophysical aspects of eIF4E and its function in vivo, including both long-established roles in translation and newly emerging ones in nuclear export and mRNA decay pathways.

PMID:
15164008
DOI:
10.1038/nsmb779
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center