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Nat Prod Rep. 2004 Jun;21(3):321-52. Epub 2004 May 3.

Enzymatic catalysis of the Diels-Alder reaction in the biosynthesis of natural products.

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1
Division of Chemistry, Graduate School of Science, Hokkaido University, Kita-ku Kita 10 Jo Nishi 8 Chome, Sapporo 060-0810, Japan.

Abstract

Recent studies on enzymes catalyzing the Diels- Alder reaction. often named "Diels-Alderases", clearlydemonstrated the involvement of this synthetically useful reaction in the biosynthesis of natural products.This review covers natural Diels-Alder type cycloadducts. synthetic efforts on the chemical feasibility ofthe biosynthctic Diels - Alder reaction and a brief history of studies on Diels-Alderases. In addition,reaction mechanisms of artificial and natural Diels--Alderases are discussed.

PMID:
15162222
DOI:
10.1039/b305068h
[Indexed for MEDLINE]
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