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Cytogenet Genome Res. 2004;104(1-4):142-8.

Quantitative analysis of radiation-induced chromosome aberrations.

Author information

1
Department of Mathematics, University of California at Berkeley, Berkeley, CA 94720, USA. sachs@math.berkeley.edu

Abstract

We review chromosome aberration modeling and its applications, especially to biodosimetry and to characterizing chromosome geometry. Standard results on aberration formation pathways, randomness, dose-response, proximity effects, transmissibility, kinetics, and relations to other radiobiological endpoints are summarized. We also outline recent work on graph-theoretical descriptions of aberrations, Monte-Carlo computer simulations of aberration spectra, software for quantifying aberration complexity, and systematic links of apparently incomplete with complete or truly incomplete aberrations.

PMID:
15162028
DOI:
10.1159/000077479
[Indexed for MEDLINE]

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