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Am J Pathol. 2004 Jun;164(6):1875-82.

Physiological and pathological responses to hypoxia.

Author information

1
Laboratoire de Biochimie et Biologie Cellulaire, University of Namur, Namur, Belgium. carine.michiels@fundp.ac.be

Abstract

As the average age in many countries steadily rises, heart infarction, stroke, and cancer become the most common causes of death in the 21st century. The causes of these disorders are many and varied and include genetic predisposition and environmental influences, but they all share a common feature in that limitation of oxygen availability participates in the development of these pathological conditions. However, cells and organisms are able to trigger an adaptive response to hypoxic conditions that is aimed to help them to cope with these threatening conditions. This review provides a description of several systems able to sense oxygen concentration and of the responses they initiate both in the acute and also in long-term hypoxia adaptation. The role of hypoxia in three pathological conditions, myocardial and cerebral ischemia as well as tumorigenesis, is briefly discussed.

PMID:
15161623
PMCID:
PMC1615763
DOI:
10.1016/S0002-9440(10)63747-9
[Indexed for MEDLINE]
Free PMC Article

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