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Vaccine. 2004 Feb 25;22(8):1007-15.

Trypanosome microtubule-associated protein p15 as a vaccine for the prevention of African sleeping sickness.

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Department of Nutrition, University of California, One Shields Avenue, Meyer Hall, Room 3135, Davis, CA 95616, USA.


Trypanosomes cause African sleeping sickness, affecting millions of humans and animals. We tested trypanosome microtubule-associate protein (MAP p15) as a vaccine in mice, and show that p15 (native or recombinant) generated up to 100% protection from an otherwise lethal challenge of a heterologous strain of Trypanosoma brucei. We also tested the adenovirus as a vaccine delivery system and show that both adenoviral vector containing p15 gene or control adenovirus containing lacZ gene generated a protective response and exhibited strong CD8+ T-cell proliferation. These results suggest that the p15 protein itself is an effective vaccine and that the adenovirus may be used to mount a non-specific cellular immune response.

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