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Microbes Infect. 2004 May;6(6):630-6.

What kind of message does IL-12/IL-23 bring to macrophages and dendritic cells?

Author information

1
Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, Sao Paulo, Brazil. krbastos@usp.br

Abstract

The present review illustrates the current knowledge on the autocrine effect of IL-12, and the putative contribution of IL-23, on macrophages and dendritic cells, focusing on cell activation and microbicidal activity. Here, we present convincing evidence that IL-12 is not only a connective element between accessory cells and lymphocytes, but it is also a key molecule for programming the macrophage and dendritic cell functions.

PMID:
15158199
DOI:
10.1016/j.micinf.2004.02.012
[Indexed for MEDLINE]

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