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Methods. 2004 Jul;33(3):260-3.

Assaying the DNA damage checkpoint in fission yeast.

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Department of Pharmacology, UMDNJ-Robert Wood Johnson Medical School and Joint Graduate Program in Cellular and Molecular Pharmacology, The State University of New Jersey, Piscataway, NJ 08854-5635, USA.


Cell cycle checkpoints exist to ensure the proper maintenance and stable inheritance of genomic information. The pathways that insure the faithful execution of these checkpoints are well conserved throughout evolution. In the fission yeast, Schizosaccharomyces pombe, a major cell cycle checkpoint exists that responds to the presence of damaged DNA and prevents this damage from being propagated to future generations. Fission yeast is an ideal system to investigate these pathways because there exist specific techniques that allow one to assay the fidelity of this DNA damage checkpoint pathway.

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