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Trends Cell Biol. 1996 Jan;6(1):15-22.

Semaphorins: mediators of repulsive growth cone guidance.

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Dept of Neuroscience, The Johns Hopkins University School of Medicine, 725 N. Wolfe St, Baltimore, MD 21205, USA.


During development, neuronal growth cones encounter a variety of guidance cues while mediating axon path finding, target recognition and synapse formation. It is clear that repulsive guidance mechanisms play an essential role in these processes. The semaphorin gene family, which is conserved from invertebrates to mammals, includes members that mediate repulsive guidance. Molecular and cellular analysis of this gene family is providing insight into how inhibitory cues function during neurodevelopment.

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