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Neuron. 2004 May 27;42(4):529-33.

p75NTR is positively promiscuous: novel partners and new insights.

Author information

1
Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, Quebec, Canada. phil.barker@mcgill.ca

Abstract

Although identified almost 20 years ago, the precise physiological role of the p75 neurotrophin receptor (p75NTR) has remained elusive. Recent studies have revealed that p75NTR is a component of three distinct receptor platforms that bind different ligands and that, under differing circumstances, facilitate cell survival, cell death, or growth inhibition. These recent developments provide new insights into the functions of this enigmatic receptor.

PMID:
15157416
DOI:
10.1016/j.neuron.2004.04.001
[Indexed for MEDLINE]
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