Abstract
Recent efforts to understand the contribution of neuronal activity in the creation of the olfactory sensory map have focused on odor-evoked events. In this issue of Neuron, Yu et al. discover a new role for neuronal activity in the organization and maintenance of the olfactory system. Their results highlight the role of spontaneous activity and synaptic transmission in axon outgrowth and olfactory neuron survival.
MeSH terms
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Animals
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Cell Differentiation / genetics*
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Gene Expression Regulation, Developmental / genetics*
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Growth Cones / metabolism
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Growth Cones / ultrastructure
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Humans
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Olfactory Bulb / cytology
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Olfactory Bulb / growth & development*
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Olfactory Bulb / metabolism
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Olfactory Mucosa / cytology
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Olfactory Mucosa / growth & development
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Olfactory Mucosa / metabolism
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Presynaptic Terminals / metabolism*
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Presynaptic Terminals / ultrastructure
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Receptors, Odorant / biosynthesis
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Receptors, Odorant / genetics
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Smell / genetics
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Smell / physiology*