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Nat Med. 2004 Jun;10(6):591-3. Epub 2004 May 23.

PrPSc accumulation in myocytes from sheep incubating natural scrapie.

Author information

1
UMR INRA ENVT 1225, Interactions Hôte Agent Pathogène, Ecole Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, 31076 Toulouse, France. o.andreoletti@envt.fr

Abstract

Because variant Creutzfeldt-Jakob disease (vCJD) in humans probably results from consumption of products contaminated with tissue from animals with bovine spongiform encephalopathy, whether infectious prion protein is present in ruminant muscles is a crucial question. Here we show that experimentally and naturally scrapie-affected sheep accumulate the prion protein PrP(Sc) in a myocyte subset. In naturally infected sheep, PrP(Sc) is detectable in muscle several months before clinical disease onset. The relative amounts of PrP(Sc) suggest a 5,000-fold lower infectivity for muscle as compared to brain.

PMID:
15156203
DOI:
10.1038/nm1055
[Indexed for MEDLINE]

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