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Nat Struct Mol Biol. 2004 Jun;11(6):576-7. Epub 2004 May 23.

Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain.

Author information

1
European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany.

Abstract

We describe the solution structures of the Argonaute2 PAZ domain bound to RNA and DNA oligonucleotides. The structures reveal a unique mode of single-stranded nucleic acid binding in which the two 3'-terminal nucleotides are buried in a hydrophobic cleft. We propose that the PAZ domain contributes to the specific recognition of siRNAs by providing a binding pocket for their characteristic two-nucleotide 3' overhangs.

PMID:
15156196
DOI:
10.1038/nsmb777
[Indexed for MEDLINE]

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