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Oncogene. 2004 May 24;23(24):4211-9.

Structure and regulated expression of mammalian RUNX genes.

Author information

1
Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel.

Abstract

The RUNX are key regulators of lineage-specific gene expression in major developmental pathways. The expression of RUNX genes is tightly regulated, leading to a highly specific spatio/temporal expression pattern and to distinct phenotypes of gene knockouts. This review highlights the extensive structural similarities between the three mammalian RUNX genes and delineates how regulation of their expression at the levels of transcription and translation are orchestrated into the unique RUNX expression pattern.

PMID:
15156175
DOI:
10.1038/sj.onc.1207670
[Indexed for MEDLINE]

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