Format

Send to

Choose Destination
Cytokine. 1992 Jul;4(4):281-6.

Biological effects of recombinant vaccinia virus-expressed interleukin 4.

Author information

1
CSIRO Australian Animal Health Laboratory, Victoria, Australia.

Erratum in

  • Cytokine 1993 Jan;5(1):89.

Abstract

Recombinant vaccinia viruses expressing murine interleukin 4 (IL-4), either alone or together with interleukin 2 (IL-2) or gamma interferon (gamma-IFN), were constructed. Unlike IL-2, IL-4 expressing viruses were not cleared from immunodeficient mice and the mice died. As they died more rapidly than immunodeficient mice inoculated with a control virus, it appeared that IL-4 contributed to their death and the IL-4 mediated toxicity was confirmed in normal immunocompetent mice. The toxicity was reversed by co-expression of either IL-2 or gamma-IFN, probably due to virus clearance and therefore lower levels of circulating IL-4. Vaccinia virus-expressed IL-4 did not increase antibody or natural killer cell levels and caused a slight decrease in cytotoxic T lymphocyte levels.

PMID:
1515552
DOI:
10.1016/1043-4666(92)90068-3
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center