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Br J Cancer. 2004 May 4;90(9):1825-9.

Co-targeting IGF-1R and c-kit: synergistic inhibition of proliferation and induction of apoptosis in H 209 small cell lung cancer cells.

Author information

1
Lady Davis Institute for Medical Research and Department of Oncology, McGill University, Montréal, QC, Canada.

Abstract

Most small cell lung cancers (SCLC) coexpress the c-kit protein tyrosine receptor kinase and its ligand stem cell factor, resulting in an autocrine loop. As SCLC growth is also driven by insulin-like growth factor-1 receptor (IGF-1R) signalling, tyrphostins AG 1024 and 1296 (inhibitors of IGF-1R and c-kit activity, respectively) were used to co-target these receptors in H 209 SCLC cells. Combination treatment caused synergy in proliferation inhibition and in apoptosis induction, and also enhanced reduction in phosphorylation of Erk1/Erk2, suggesting that co-targeting IGF-1R and c-kit in SCLC may be more effective than single-agent therapies.

PMID:
15150607
PMCID:
PMC2409731
DOI:
10.1038/sj.bjc.6601682
[Indexed for MEDLINE]
Free PMC Article

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