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J Histochem Cytochem. 2004 Jun;52(6):789-95.

Presence of collagen IV in the ciliary zonules of the human eye: an immunohistochemical study by LM and TEM.

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University Hospital/University of Groningen, Department of Ophthalmology, Groningen, The Netherlands.


The ciliary zonules of the eye are composed of fibrillar and non-fibrillar components. Fibrils provide tensile strength and elasticity, whereas non-fibrillar components serve as a coating surrounding the fibrils. This coating behaves as a barrier to macromolecules. The present light and transmission electron microscopic (LM and TEM) study identified collagen IV as a novel component of this coating. Collagen IV was demonstrated by pre-embedding and postembedding immunohistochemical (IHC) techniques using monoclonal and polyclonal antibodies. The specificity of the polyclonal anticollagen IV antibody was verified by ELISA.

[Indexed for MEDLINE]

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