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Bioorg Med Chem Lett. 2004 Jun 21;14(12):3351-5.

Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720.

Author information

1
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. jeffrey_hale@merck.com

Abstract

Alteration in lymphocyte trafficking and prevention of graft rejection in rodents observed on exposure to FTY720 (1) or its corresponding phosphate ester 2 can be induced by the systemic administration of potent sphingosine-1-phosphate receptor agonists exemplified by 19. The similar S1P receptor profiles of 2 and 19 coupled with their comparable potency in vivo supports a connection between S1P receptor agonism and immunosuppressive efficacy.

PMID:
15149705
DOI:
10.1016/j.bmcl.2004.02.106
[Indexed for MEDLINE]

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