Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2004 Jun 21;14(12):3165-8.

Structure-based design, synthesis, and antimicrobial activity of purine derived SAH/MTA nucleosidase inhibitors.

Author information

1
Department of Medicinal Chemistry, Quorex Pharmaceuticals, Carlsbad, CA 92008, USA.

Abstract

The structure-based design, synthesis, and biological activity of novel inhibitors of S-adenosyl homocysteine/methylthioadenosine (SAH/MTA) nucleosidase are described. Using 6-substituted purine and deaza purines as the core scaffolds, a systematic and structure guided series of modifications provided low nM inhibitors with broad-spectrum antimicrobial activity.

PMID:
15149667
DOI:
10.1016/j.bmcl.2004.04.006
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center