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Bioorg Med Chem Lett. 2004 Jun 21;14(12):3155-9.

In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase.

Author information

1
Department of Chemistry Research, Bayer Research Center, 400 Morgan Lane, West Haven, CT 06516, USA. derek.lowe.b@bayer.com

Abstract

A series of (5-(2H)-isoxazolonyl) ureas were developed as nanomolar inhibitors of hormone-sensitive lipase, an enzyme of potential importance in the treatment of diabetes.

PMID:
15149665
DOI:
10.1016/j.bmcl.2004.04.015
[Indexed for MEDLINE]

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