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Bioorg Med Chem Lett. 2004 Jun 21;14(12):3131-4.

Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases.

Author information

1
Gorlaeus Laboratories, Leiden University, Einsteinweg 55, 2300 RA Leiden, The Netherlands.

Abstract

Quantification studies of complex protein mixtures have been restricted mainly to whole cell extracts. Here we describe the synthesis of two sets of isotope-coded activity-based probes that allow quantitative functional proteomics experiments on the cathepsins.

PMID:
15149659
DOI:
10.1016/j.bmcl.2004.04.046
[Indexed for MEDLINE]

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