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Bioorg Med Chem Lett. 2004 Jun 21;14(12):3053-6.

N-isoquinolin-5-yl-N'-aralkyl-urea and -amide antagonists of human vanilloid receptor 1.

Author information

1
Johnson & Johnson Pharmaceutical Research and Development, Welsh and McKean Roads, Spring House, PA 19477, USA.

Abstract

Starting from a low micromolar agonist lead identified by high-throughput screening, series of N-isoquinolin-5-yl-N'-aralkyl ureas and analogous amides were developed as potent antagonists of human vanilloid receptor 1 (VR1). The synthesis and structure-activity relationships (SAR) of the series are described.

PMID:
15149643
DOI:
10.1016/j.bmcl.2004.04.038
[Indexed for MEDLINE]

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