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Mol Cell. 2004 May 21;14(4):414-6.

Control of DNA synthesis and mitosis by the Skp2-p27-Cdk1/2 axis.

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Department of Pathology, New York University School of Medicine and NYU Cancer Institute, 550 First Avenue, MSB 599, New York, NY 10016, USA.


A new study reveals a novel role for p27 in inhibiting Cdk1 activity at G2/M and shows that p27 deficiency almost completely rescues the aberrations observed in Skp2(-/-) mice, demonstrating that p27 is the principal downstream effector of the SCF(Skp2) ubiquitin ligase.

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