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Zhonghua Nan Ke Xue. 2004 Apr;10(4):265-8.

[Expression and significance of activated leukocyte cell adhesion molecule in prostatic intraepithelial neoplasia and adenocarcinoma].

[Article in Chinese]

Author information

1
Department of Urology, First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, Zhejiang 310003, China. zhengxy@hz.cn

Abstract

OBJECTIVE:

To investigate the expression of activated leukocyte cell adhesion molecule(ALCAM) protein in prostatic intraepithelial neoplasia and adenocarcinoma, and the relationship between ALCAM expression and clinicopathological features of prostatic carcinoma.

METHODS:

ALCAM protein expression was evaluated in the tissues of 41 human prostatic carcinomas by using immunohistochemistry (EnVision method).

RESULTS:

ALCAM was widely expressed in prostatic epithelia. Overexpression of ALCAM was found in most prostatic intraepithelial neoplasias and low-grade cancers, whereas a decreased expression shown in some high-grade cancers. The ALCAM protein expression in prostatic carcinoma was correlated with pathological grading. However, no correlation of ALCAM expression was found with preoperative serum prostate-specific antigen levels or clinical stages.

CONCLUSION:

Expression of ALCAM is disturbed in prostatic intraepithelial neoplasia and adenocarcinoma, indicating its involvement in the development of human prostatic carcinoma.

PMID:
15148921
[Indexed for MEDLINE]

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