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Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8378-83. Epub 2004 May 17.

phyllopod is a target gene of proneural proteins in Drosophila external sensory organ development.

Author information

1
Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan.

Abstract

Proneural basic helix-loop-helix (bHLH) proteins initiate neurogenesis in both vertebrates and invertebrates. The Drosophila Achaete (Ac) and Scute (Sc) proteins are among the first identified members of the large bHLH proneural protein family. phyllopod (phyl), encoding an ubiquitin ligase adaptor, is required for ac- and sc-dependent external sensory (ES) organ development. Expression of phyl is directly activated by Ac and Sc. Forced expression of phyl rescues ES organ formation in ac and sc double mutants. phyl and senseless, encoding a Zn-finger transcriptional factor, depend on each other in ES organ development. Our results provide the first example that bHLH proneural proteins promote neurogenesis through regulation of protein degradation.

PMID:
15148389
PMCID:
PMC420402
DOI:
10.1073/pnas.0306010101
[Indexed for MEDLINE]
Free PMC Article

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