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J Exp Med. 2004 May 17;199(10):1295-9.

Human Mannose-binding Lectin in Immunity: Friend, Foe, or Both?

Author information

1
Pediatric Hematology-Immunology Unit, Necker Enfants-Malades Hospital, Paris, France. casanova@necker.fr

Abstract

Human mannose-binding lectin (MBL) recognizes a wide range of microorganisms and triggers the most ancient pathway of complement activation. However, approximately 5% of individuals lack functional serum MBL and have not been found to be prone to severe infections in prospective studies. These data suggest that human MBL is largely redundant for protective immunity and may even have been subject to counter selection because of a deleterious impact.

PMID:
15148331
PMCID:
PMC2211810
DOI:
10.1084/jem.20040537
[Indexed for MEDLINE]
Free PMC Article

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