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Arch Neurol. 2004 May;61(5):762-6.

Copper deficiency myelopathy.

Author information

1
Department of Neurology, Mayo Clinic, Mayo Foundation, Rochester, Minn, USA. kumar.neeraj@mayo.edu

Abstract

BACKGROUND:

In humans, Menkes disease is the well-recognized neurological disorder due to inherited copper deficiency. Myelopathy due to acquired copper deficiency is not a well-recognized entity in humans, although myelopathy due to copper deficiency is well documented in some animal species.

PATIENTS:

We describe 3 patients who developed a progressive spastic-ataxic gait with proprioceptive deficits. All patients had a severe reduction in serum ceruloplasmin and copper levels.

RESULTS:

All patients had evidence of posterior column dysfunction clinically and on somatosensory evoked potential studies. Two had a signal change in the posterior column on magnetic resonance imaging of the spinal cord.

CONCLUSION:

Patients presenting with otherwise unexplained myelopathies should have their serum ceruloplasmin level measured.

PMID:
15148156
DOI:
10.1001/archneur.61.5.762
[Indexed for MEDLINE]

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