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Ann Emerg Med. 1992 Sep;21(9):1116-21.

Ketorolac versus meperidine and hydroxyzine in the treatment of acute migraine headache: a randomized, prospective, double-blind trial.

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  • 1Department of Emergency Medicine, University of Illinois College of Medicine, Peoria.

Abstract

STUDY OBJECTIVE:

To compare the effectiveness of IM ketorolac with that of meperidine and hydroxyzine in the treatment of acute migraine headache.

DESIGN:

Prospective, randomized, double-blind trial.

SETTING:

Urban emergency department with an annual census of 42,000 patients.

PARTICIPANTS:

Forty-seven adult patients with migraines enrolled on 50 visits.

INTERVENTIONS:

Patients were randomly assigned to receive a single injection of either 60 mg ketorolac (group 1) or 100 mg meperidine and 50 mg hydroxyzine (group 2). Pain assessment was made using both visual-analog and verbal descriptor scales.

RESULTS:

At 60 minutes, 15 patients (60%) from group 1 (25) and 14 patients (56%) from group 2 (25) reported a great deal of complete relief (P = .77) Sixty-minute mean pain relief scores (3.35 versus 3.37) were different (P = .76). Nine patients (36%) from group 1 and seven patients (28%) from group 2 required additional analgesia (P = .76).

CONCLUSION:

Ketorolac is as effective as meperidine and hydroxyzine for the treatment of acute migraine headache.

PMID:
1514724
[PubMed - indexed for MEDLINE]
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