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Nat Neurosci. 2004 Jun;7(6):585-6. Epub 2004 May 16.

A single in-vivo exposure to delta 9THC blocks endocannabinoid-mediated synaptic plasticity.

Author information

1
Equipe INSERM Avenir, Plasticité synaptique: Maturation & Addiction, Institut Magendie des Neurosciences, Rue Camille Saint Saëns, 33077 Bordeaux, France.

Abstract

Endogenous cannabinoids (eCB) mediate synaptic plasticity in brain regions involved in learning and reward. Here we show that in mice, a single in-vivo exposure to Delta 9-tetrahydrocannabinol (THC) abolishes the retrograde signaling that underlies eCB-mediated synaptic plasticity in both nucleus accumbens (NAc) and hippocampus in vitro. This effect is reversible within 3 days and is associated with a transient modification in the functional properties of cannabinoid receptors.

PMID:
15146190
DOI:
10.1038/nn1251
[Indexed for MEDLINE]

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