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Curr Opin Cell Biol. 2004 Jun;16(3):293-9.

Nonsense-mediated mRNA decay: terminating erroneous gene expression.

Author information

1
Howard Hughes Medical Institute, University of Arizona, 1007 East Lowell Street, Tucson, Arizona 85721, USA.

Abstract

Nonsense-mediated mRNA decay is a surveillance pathway that reduces errors in gene expression by eliminating aberrant mRNAs that encode incomplete polypeptides. Recent experiments suggest a working model whereby premature and normal translation termination events are distinct as a consequence of the spatial relationship between the termination codon and mRNA binding proteins, a relationship partially established by nuclear pre-mRNA processing. Aberrant termination then leads to both translational repression and an increased susceptibility of the mRNA to multiple ribonucleases.

PMID:
15145354
DOI:
10.1016/j.ceb.2004.03.003
[Indexed for MEDLINE]

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